تجمعات نانویی توده های متراکم j بر پایه ی استفاده از NIR به عنوان دارویی چند وظیفه ای
" تجمعات نانویی توده های متراکم j بر پایه ی استفاده از NIR به عنوان دارویی چند وظیفه ای (چند کاره یا چند متغیره)که حامل ترکیبات درمانی سرطان هستند لایه نشانی می شوند"
شیمی درمانی به طور گسترده به عنوان یک استراتژی درمان سرطان در کلنیک اعمال می شود. ولی از آنجایی که شیمی درمانی عوارضی دارد، ترکیب شیمی درمانی با سایر استراتژی های درمانی برای کشتن سرطان با شیوه های هم افزایی پیشنهاد شده است.
در سال های اخیر از سیستم های داروسازی (DDS) که قادر است به طور همزمان به جذب مادون قرمز NIR برای رسیدن به اثر هم افزایی توسعه یافته اند.
برای تحقق بخشیدن به ترکیب گرمانوری و شیمی درمانی، حامل مناسب دارو براساس جذب منطقه نزدیک به مادون قرمز NIR عامل گرمانوری مورد نیاز است.
در چند سال گذشته پلیمر دوگانه ارگانیکبا موفقیت به عنوان عوامل گرمانوری قادر به شیمی درمانی استفاده می شود.
در اینجا ما با موفقیت نوع جدیدی از DDS برپایه ی استفاده ازتوده های متراکمj مولکول های کوچک لایه نشانی شده برای ترکیب گرمانوری و شیمی درمانی ساختیم.
توده های متراکم j از IR 825 بنیادی لایه نشانی شده، مرکب شده با پلیمر کاتیونی PEI و درهم امیختن با PEG نشان می دهد اوج جذب انتقال به سرخ به طور قابل توجهی افزایش یافته در 915 نانومتر.
تشکیل نانو ذراتPEI-PEG IR825@نشان میدهد ثبات نوری بیشتر پس از چند دور استفاده از حرارت گرمانوری، یک رفتار شگرف مافوق نسبت به ICG، از NIR لایه نشانی شده بالینی را تایید می کند .
در این سیستم، IR825 نه تنها به عنوان جذب NIR عامل گرمانوری عمل می کند، بلکه به عنوان مرکز آبگریز (قادر به جذب یا ترکیب شدن با اب را ندارد) برای جذب ناکووالان مولکول های DOX برای تحویل شیمی درمانی عمل می کند.
با یک استراتژی بارگذاری دارو کاملا منحصر به فرد بدون استفاده از پلیمرهای amphiphilic، IR825@PEI-PEG/DOX بهره وری بارگذاری بالا از مقدار موثر در مقایسه با DDS متداول ارگانیک بر اساسliposome ها یا micelle ها را نشان داد.
پس ازتزریق i.v. روی سیستم بدن، IR825@PEI-PEG/DOX گردش خون نیمه عمر طولانی و تجمع موثر تومور منفعل نشان می دهد، دومی اینکه هم چنین توسط تصویربرداری فوتواکوستیک در داخل بدنتایید می کند.
علاوه بر این، اثر درمانی مربوط به همکاری برجسته ما در داخل بدن ترکیب گرمانوری و شیمی درمانی بر روی یک مدل تومور موش نتیجه استفاده از IR825@PEI-PEG/DOX است، که نشان نمی دهد هیچگونه سمیت حاد آشکار به حیوانات در دوز درمانی.
به طور موثر درمان تومورهای با حرارت گرمانوری کم علاوه بر شیمی درمانی ممکن است مزایای بیش از درمان گرمانوری ساده به نابودی تومورهای با حرارت دادن در دمای بالا داشته باشد، به خصوص هنگام درمان تومورهای بزرگ که دشوار خواهد بود برای ارائه قدرت نور کافی.
این کار ارائه یک استراتژی بارگذاری دارو جدید بر اساس تجمعات نانویی مولکول های کوچک برای مهندسی سیستم عامل DDS با زیست سازگاری خوب، راندمان بارگذاری بالا، توابع چندگانه، و توانایی های رهنمودی تومور غیر فعال است.
یک طرح برای نشان دادن روند ساخت IR825@PEI-PEG/DOX :
UV-VIS-NIR طیف جذبی از IR825@PEI-PEG و IR825 در micelle :
UV-VIS-NIR طیف جذبی از IR825@PEI-PEG و IR825@PEI-PEG/DOX :
تصویر شماتیک نشان می دهد که جذب سلولی IR825@PEI-PEG/DOX را می توان با حرارت گرمانوری ناشی از لیزر افزایش یافت
گردآورنده : سهیلا کاووسی
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